Cardiothoracic Surgery
Your Clear Solution for Cardioplegia and
Heart Transplantation
CUSTODIOL®
Cardioplegia with unique benefits
- Cardioplegia: Professor Bretschneider broadened the defi nition of “cardioplegia” to be a synonym for “myocardial protection”. The histidine-tryptophanketoglutarate solution (HTK) CUSTODIOL®, has been originally designed in order to provide an optimal myocardial protection
- One of the only two well-documented methods of cardioplegia: Bretschneider’s and Buckberg’s principles of cardioplegia are the only techniques, which offer a proven track record of published clinical studies
- Nondepolarizing cardiac arrest: The low-to-moderate content of electrolytes (“intracellular”-type cardioplegic solution, 15 mM sodium) mean less cellular stress during cold ischemia, especially since the cell membranes are protected by tryptophan
- A single/initial application applied over the period of 6-8 minutes is suffi cient for up to 180 minutes of myocardial ischemia
- Superior energetic protection (ATP): Energy substrates and high buffering capacity offer the basis for both anaerobic energy supply during ischemia and full return to function upon reperfusion